Emerging Research Links Gut Microbiome to Metabolic Health

Findings Offer New Pathways for the Dietary Management of Type 2 Diabetes

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Materials for You

• Glucose Control Fact Sheet

Materials for Patients and Clients

• Patient Pamphlet
• Top HCP Q&A
• HCP Overview Sheet
• Pendulum Partners Information

The Role of the Gut Microbiome and Type 2 Diabetes Management

Research shows that two imbalances in the gut microbiome are linked to Type 2 diabetes.^1-4

1. The first is a deficiency in the functional ability to produce short-chain fatty acids, such as butyrate, produced when some dietary fibers are metabolized by the gut microbiome. Butyrate binds to specific receptors within the gut mucosa and stimulates the release of the incretin hormone, glucagon-like peptide-1 (GLP-1).
2. The second imbalance is an impaired functional ability to maintain the mucin layer of the gut lining.

These two imbalances contribute to development of Type 2 diabetes.

Studies also suggest that the presence of healthy bacteria such as Akkermansia muciniphila is inversely related to the incidence of Type 2 diabetes and plays a crucial role in the maintenance of the microbiome. Published research suggests improving the health of the gut microbiome may offer new pathways to augment the dietary management of Type 2 diabetes.^5,6 Evidence (in-press) from preclinical studies and other small pilot clinical studies suggest reviving the body’s ability to produce short-chain fatty acids and restoring the mucin layer of the gut positively affects the management of Type 2 diabetes.

Pendulum Glucose Control: Mechanism of Action

Pendulum Glucose Control is a first-of-its-kind formulation of both probiotics and a prebiotic clinically shown to assist with the dietary management of people with Type 2 diabetes.² In a double-blind, randomized, placebo-controlled study, Pendulum Glucose Control reduced A1c levels by 0.6% compared to placebo and generated a 33% reduction in postprandial glucose spikes (Area Under the Curve or AUC) in individuals with Type 2 diabetes taking metformin. Pendulum Glucose Control is changing dietary management of type 2 diabetes.

PGC is intended for use under medical supervision. The FDA has not approved or evaluated these statements. PGC is not intended to diagnose, treat, cure, or prevent any diseases, but instead is intended for the dietary management of diabetes.

References

1. Mishra SP, Jain S, Taraphder S, Yadav H. New horizons in microbiota and metabolic health research. J Clin Endocrin Metab. 2021;106(2):e1052-e1059. doi:10.1210/clinem/dgaa769
2. Perraudeau F, McMurdie P, Bullard J, et al. Improvements to postprandial glucose control in subjects with type 2 diabetes: a multicenter, double blind, randomized placebo-controlled trial of a novel probiotic formulation. BMJ Open Diabetes Res Care. 2020;8:e001319. doi:10.1136/bmjdrc-2020-001319
3. Herrema H, Niess JH. Intestinal microbial metabolites in human metabolism and type 2 diabetes. Diabetologia. 2020;63:2533-2547. doi:10.1007/s00125-020-05268-4
4. Zhao L, Zhang F, Ding Z, et al. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science. 2018;359(6380):1151-1156. doi:10.1126/science.aao5774
5. Schwartz, SS, Epstein S, Corkey BE, et al. The time is right for a new classification system for diabetes: rationale and implications of the β-cell-centric classification schema. Diabetes Care. 2016;39:179-186. doi:10.2337/dc15-1585
6. Bock PM, Telo GH, Ramalho R, et al. The effects of probiotics, prebiotics or synbiotics on metabolic outcomes in individuals with diabetes: a systematic review and meta analysis. Diabetologia. 2021;64:26-41. doi:10.1007/s00125-020-05295-1