Obesity, Metabolic Syndrome Associated With Impaired Brain Function in Teens

A new study by researchers at NYU School of Medicine reveals for the first time that metabolic syndrome (MetS) is associated with cognitive and brain impairments in adolescents and calls for pediatricians to take this into account when considering the early treatment of childhood obesity. The study appears online in Pediatrics.

As childhood obesity has increased in the United States, so has the prevalence of metabolic syndrome. Lead investigator Antonio Convit, MD, a professor of psychiatry and medicine at NYU School of Medicine and a member of the Nathan Kline Research Institute, and colleagues have shown previously that metabolic syndrome has been linked to neurocognitive impairments in adults, but this association was generally thought to be a long-term effect of poor metabolism. Now, the research team has revealed even worse brain impairments in adolescents with metabolic syndrome, a group absent of clinically manifest vascular disease and likely shorter duration of poor metabolism.

“The prevalence of MetS parallels the rise in childhood obesity,” Convit says. “There are huge numbers of people out there who have problems with their weight. If those problems persist long enough, they will lead to the development of MetS and diabetes. As yet, there has been very little information available about what happens to the brain in the setting of obesity and MetS and before diabetes onset in children.”

For the study, the researchers compared 49 adolescents with metabolic syndrome with 62 teens without the disorder. Of those who were not in the MetS group, 40% were considered overweight or obese, so while they were not in ideal health, they did not have three out of the five health issues needed to fall into the MetS group. The findings reported, therefore, are conservative and reflective of the real world.

Convit and colleagues balanced each group according to age, socioeconomic status, school grade, gender, and ethnicity to ensure things like cultural differences in diet and access to quality healthcare did not cloud the data. They then conducted endocrine, MRI and neuropsychological evaluations on the adolescents and found that those classified as having MetS showed significantly lower math and spelling scores, as well as decreased attention span and mental flexibility. They also showed differences in brain structure and volume, presenting with smaller hippocampal volumes—involved in the learning and recall of new information, increased brain cerebrospinal fluid and reductions of microstructural integrity in major white matter tracts in the brain. The more MetS-characterizing health problems the participants had, the more profound the effect across the board.

“The kids with MetS took longer to do tasks, could not read as well and had poorer math scores,” Convit says. “These findings indicate that kids with MetS do not perform well on things that are very relevant to school performance.”

The researchers concluded that even a few years of problems with metabolism may cause brain complications. They suggest the adverse impact of MetS on brain function in children could be used by pediatricians as a powerful motivator to get families more involved in meaningful lifestyle change.

“Only now are pediatricians becoming aware of some of these issues,” Convit explains. “Many pediatricians don’t even take a blood pressure, and they certainly are not taking cholesterol levels and testing insulin resistance.” He adds that about one-third of children who are obese have abnormal cholesterol levels and more than 40% of those who are really obese have insulin resistance. “Obesity in kids is sky-high. Nearly 40% of the US population is considered obese. Parents need to understand that obesity has medical consequences, even in children, and some of those consequences may be impacting more than just the long term health of the cardiovascular system. We need to do what our grandmothers have told us all along: ‘Eat well, don’t overeat and try to move as much as possible.’”

Convit adds that simple changes in daily routine would go a long way in preventing MetS—changes like walking more and taking the stairs. Future research is needed to determine whether the reductions in cognitive performance and structural brain abnormalities are reversible with significant weight loss, he explains.

“The take home message is that just being overweight and obese is already impacting your brain,” Convit says. “Kids who are struggling with their weight and moving toward having MetS may have lower grades, which could ultimately lead to lower professional achievement in the long run. These are run-of-the-mill, garden-variety kids, not kids that came into the hospital because they were sick. It is imperative that we take obesity and physical activity seriously in children. In this country, we’re taking away gym class in order to give children more class time in an effort to improve school performance, but that effort may be having the exact opposite effect.”

Source: NYU Langone Medical Center

ADVERTORIAL