Fish Oil Supplements May Protect Against Type 2 Diabetes

Fish oil supplements modestly increase the amounts of a hormone associated with lower risk of diabetes and heart disease, according to a study accepted for publication in the Journal of Clinical Endocrinology & Metabolism.

Fish oil supplements raise the level of adiponectin in the bloodstream. Adiponectin is a hormone that beneficially affects metabolic processes such as glucose regulation and inflammation modulation. In long-term human studies, higher levels of adiponectin are associated with a lower risk of type 2 diabetes and coronary heart disease.

“While prior animal studies found fish oil increased circulating adiponectin, whether similar effects apply in humans is not established,” says the study’s lead author, Jason Wu, PhD, of the Harvard School of Public Health. “By reviewing evidence from existing randomized clinical trials, we found that fish oil supplementation caused modest increases in adiponectin in the blood of humans.”

The meta-analysis reviewed and analyzed results from 14 randomized, placebo-controlled clinical trials. In total, 682 subjects were treated with fish oil, and 641 were given placebos—most commonly olive and sunflower oils. In those taking fish oil, adiponectin levels increased by 0.37 mcg/mL. The results also suggested the effect of fish oil on adiponectin differed substantially across the trials, suggesting that fish oil supplementation may have a stronger influence on adiponectin in some populations and weaker effects in others.

This is the first study to pool data from previous trials to suggest that fish oil consumption increases adiponectin in humans. The findings quantify the potential impact of fish oil on adiponectin levels and highlight the need to further investigate populations that may particularly benefit from fish oil supplementation.

“Although higher levels of adiponectin in the bloodstream have been linked to a lower risk of diabetes and coronary heart disease, whether fish oil influences glucose metabolism and development of type 2 diabetes remains unclear,” Wu says. “However, results from our study suggest that higher intake of fish oil may moderately increase blood levels of adiponectin, and these results support potential benefits of fish oil consumption on glucose control and fat cell metabolism.”

Source: Endocrine Society