Link Between Ultraprocessed Foods, Colorectal Cancer

Consumption of ultraprocessed foods and drinks could increase the risk of developing colorectal cancer. This was the conclusion of a large study undertaken by the Barcelona Institute for Global Health (ISGlobal), a center supported by the "la Caixa" Foundation, based on questionnaires about food behaviors completed by around 8,000 people in Spain. The study, the first of its kind in the country, also analyzed the relationship between ultraprocessed food and drink products and two other cancers; while no association was observed with prostate cancer, in the case of breast cancer a higher risk was observed in the subgroup of former and current smokers who reported a diet high in ultraprocessed products.

Social, economic, and industrial changes have driven a rise in ultraprocessed food and drink consumption, which currently accounts for between 25% and 50% of the total energy intake in diets in Europe and in high- and middle-income countries. The Nova classification system groups all foods and drinks into four categories according to how much processing they undergo.

Ultraprocessed foods—those that undergo the most processing—are industrial formulations with more than five ingredients that usually contain additional substances, such as sugar, fats, salt, and additives. Examples of products in this category include sugary soft drinks, ready meals, and mass-produced industrial baked goods.

Several studies have linked the consumption of ultraprocessed foods and drinks to health risk factors, CVDs, type 2 diabetes, and increased risk of premature death. There are only a few studies on the relationship of these food products with cancer, and the results aren't conclusive. A French study found an association between the consumption of ultraprocessed foods and increased cancer risk. A Canadian study found an increased risk of developing prostate cancer with a higher intake of processed foods, but not with ultraprocessed foods.

The aim of the present study was to assess whether the consumption of ultraprocessed foods and drinks is associated with an increased risk of colorectal, breast, or prostate cancer. To this end, the researchers undertook a case-control study of 7,843 adults living in different Spanish provinces: One-half of the participants had a diagnosis of colorectal (1,852), breast (1,486), or prostate cancer (953); and the other half were people with the same characteristics who didn't have cancer. Data were obtained from the multi–case-control study MCC-Spain. Dietary data were collected using a validated questionnaire designed to evaluate the frequency of consumption of usual food and drink items over a one-year period. The results were then classified according to the level of processing using the Nova classification.

The study, published in Clinical Nutrition, concluded that the consumption of ultraprocessed foods and beverages is associated with an increased risk of colorectal cancer: A 10% increment in the consumption of ultraprocessed foods and drinks was found to be associated with an 11% increase in the risk of developing colorectal cancer.

Dora Romaguera, PhD, MPH, first author of the study and a researcher at ISGlobal, the Institut d'Investigació Sanitària Illes Balears (IdISBA), and the CIBEROBN, says that this relationship can be explained in part "by the low intake of fiber, fruits, and vegetables, which are known to offer protection against colorectal cancer, among people who eat a lot of ultraprocessed foods, but also by the additives and other substances with carcinogenic potential typically used in processed food products."

In the case of breast cancer, no strong relationship was found, but an association was observed in the group of current and former smokers. Romaguera explains that "smoking is a risk factor for breast cancer, and smoking and certain dietary factors, such as the consumption of ultraprocessed foods and beverages, are known to have synergetic effects on cancer development."

No association was found between prostate cancer and a diet high in ultraprocessed products. "This finding is not surprising and is consistent with the results of previous studies of dietary factors and prostate cancer risk, in which no link was found," Romaguera says.

The results of the study showed that people with breast and colorectal cancer, but not those with prostate cancer, reported less healthful diets than people without cancer in the control group. "We found differences in terms of their intake of energy, fiber, energy density, and saturated fatty acids. Consumption of ultraprocessed foods and beverages was higher among colorectal and breast cancer cases than in the controls," says ISGlobal researcher Sílvia Fernández, PhD, joint first author of the study.

The food groups that accounted for the largest proportion of ultraprocessed food consumption were sugary beverages (35%), sugary products (19%), ready-to-eat foods (16%), and processed meats (12%). Processed meats already have been classified as carcinogenic by the International Agency for Research on Cancer (IARC). However, according to Pilar Amiano, PhD, a researcher at the Guipúzcoa Public Health Service, which coordinated the study, "ultraprocessed foods and drinks in general are not yet classified as carcinogenic because the aim of the IARC was not to assess the overall risk of an individual's diet, but rather to focus on specific components that might be dangerous, such as processed meats."

She goes on to say that, in light of the results of the present study and the current scientific evidence on the health risks associated with ultraprocessed foods and drinks, in particular with respect to cancer, the authors believe "that food and public health policies and the IARC should already be taking food processing into account and discouraging the consumption of ultraprocessed products."

— Source: Barcelona Institute for Global Health