Preliminary Study Links Overweight With Stroke Survival

It may seem counterintuitive, but having some extra body fat may be linked to an increased chance of surviving a stroke, according to a preliminary study presented at the American Academy of Neurology’s 71st Annual Meeting in Philadelphia in early May.

Medical experts call such an occurrence the obesity paradox. The obesity paradox is a medical theory that suggests obesity may be protective for some people, such as very old people or those with certain chronic diseases.

“It was first noticed that carrying extra weight may play a role in survival for people who had suffered from kidney and heart disease, so we felt the need to investigate whether it also was tied to improved stroke survival,” says study author Zuolu Liu, MD, of UCLA and a member of the American Academy of Neurology.

The study looked at 1,033 people with an average age of 71 who had an acute ischemic stroke, which is a stroke where blood flow to a part of the brain is blocked. Researchers calculated participants’ BMI. People are considered overweight if they have a BMI of 25 to 29 and obese with a BMI above 29. The average BMI for the participants was 27.5.

Participants were divided into five categories based on BMI: underweight, normal, overweight, obese, and severely obese.

Researchers then monitored patients for three months following their stroke, measuring their levels of disability.

The study found that people who were severely obese were 62% less likely to die than people of normal weight. People who were obese were 46% less likely to die after a stroke, and those who were overweight were 15% less likely to die. Conversely, people who were underweight were 67% more likely to die after a stroke than people of normal weight. These results were calculated after researchers adjusted for other factors that could affect survival rates, such as high blood pressure, high cholesterol, or smoking.

Of the 95 people who were severely obese, 11 died during the study, compared with 19 of the 192 people who were obese, 58 of the 395 people who were overweight, 55 of the 327 people who were normal weight, and six of the 24 people who were underweight.

“One possible explanation is that people who are overweight or obese may have a nutritional reserve that may help them survive during prolonged illness,” Liu states. “More research is needed to investigate the relationship between body mass index and stroke.”

One limitation of the study was that all participants were from southern California, which means results may not be the same for other populations. However, the racial/ethnic distribution of the population in this study mirrors that of the national population.

— Source: American Academy of Neurology