Physical Fitness Linked to Lower Alzheimer’s Risk
People who are more physically fit are less likely to develop Alzheimer’s disease than people who are less physically fit, according to a preliminary study scheduled to be presented at the American Academy of Neurology’s 74th Annual Meeting, held in person in Seattle, April 2-7, 2022, and virtually, April 24-26, 2022.
“One exciting finding of this study is that as people’s fitness improved, their risk of Alzheimer’s disease decreased—it was not an all-or-nothing proposition,” says study author Edward Zamrini, MD, of the Washington VA Medical Center in Washington, D.C., and a member of the American Academy of Neurology. “So people can work toward making incremental changes and improvements in their physical fitness and hopefully that will be associated with a related decrease in their risk of Alzheimer’s years later.”
The study involved 649,605 military veterans in the Veterans Health Administration database with an average age of 61 who were followed for an average of nine years. They didn’t have Alzheimer’s disease at the start of the study.
Researchers determined participants’ cardiorespiratory fitness, a measure of how well the body transports oxygen to the muscles, and how well the muscles are able to absorb oxygen during exercise.
The participants were divided into five groups, from least fit to most fit. Fitness levels were determined by how well participants performed on a treadmill test that measured exercise capacity. For people who are middle-aged and older, the highest level of fitness can be achieved by walking briskly most days of the week, for 2 1/2 hours or more per week.
The group with the lowest level of fitness developed Alzheimer’s at a rate of 9.5 cases per 1,000 person-years, compared with 6.4 cases per 1,000 person-years for the most fit group. Person-years take into account the number of people in a study as well as the amount of time spent in the study. The case rate decreased as the level of fitness increased, with a rate of 8.5 for the second least fit group, 7.4 for the middle group, and 7.2 for the second most fit group.
When researchers adjusted for other factors that could affect risk of Alzheimer’s disease, they found that the people in the most fit group were 33% less likely to develop Alzheimer’s disease than those in the least fit group. The second most fit group was 26% less likely to develop the disease, while the middle group was 20% less likely, and those in the second least fit group were 13% less likely to develop the disease than those in the least fit group.
“The idea that you can reduce your risk of Alzheimer’s disease by simply increasing your activity is very promising, especially since there are no adequate treatments to prevent or stop the progression of the disease,” Zamrini says. “We hope to develop a simple scale that can be individualized so people can see the benefits that even incremental improvements in fitness can deliver.”
A limitation of the study was participants were mostly white men so results may not be generalizable to other populations.— Source: American Academy of Neurology