Bone Density Lower With Use of ADHD Medicine

Children and teenagers who take stimulant drugs to treat attention-deficit hyperactivity disorder (ADHD) may have lower bone density than their peers who do not take these medications, a new study finds. The study results were presented at the Endocrine Society's 98th annual meeting in Boston.

Stimulants, such as methylphenidate (Ritalin and other brands) and amphetamine, are frequently a treatment of ADHD, a condition that affects more than 6 million children in the United States, according to the Centers for Disease Control and Prevention (CDC).

Past research studies have found that stimulants may slow children's rate of growth in height, but the effect of these medicines on bone health is unclear, according to the study's lead investigator Alexis Feuer, MD, an assistant professor of pediatrics and a pediatric endocrinologist at Weill Cornell Medicine, New York City.

"Adolescence and young adulthood are critically important times for accruing peak bone mass—the largest and densest bone," Feuer says. "Failure to obtain adequate bone mass by early adulthood may result in an increased fracture risk or even the development of osteoporosis later in adulthood."

Their study examined an association between the use of stimulant medications and bone density, using data from the National Health and Nutrition Examination Survey (NHANES), a series of surveys from the CDC to assess the health of US adults and children. Among 6,489 people aged 8 to 20 years who participated in NHANES between 2005 and 2010 and had a bone density scan using dual-energy X-ray absorptiometry, or DXA, 159 subjects used stimulants and 6,330 didn't.

The DXA scans evaluated bone mineral density, a surrogate measurement of bone strength, as well as bone mineral content, which is the weight of bone, at both the hip and the lumbar spine (lower back). Bone mineral content is a better measure of bone health in children than is bone mineral density, Feuer states.

Among stimulant users, the average bone mineral content at the lumbar spine was 5.1% lower than in nonusers and 5.3% lower at the hip, the investigators report. Bone density was 3.9% lower in stimulant users at the spine and 3.7% lower at the hip compared with nonusers.

Feuer cautions that their study does not prove stimulant medicine is a cause of lower bone density. She says prospective research studies that evaluate bone density and bone mineral content at more than one point in time are needed to clarify the effects of stimulant medications on the skeletons of growing children.

"Our research suggests that children and adolescents who use stimulant medications may need monitoring of their bone health during and after stimulant treatment," Feuer says.

Health care providers can monitor bone health of pediatric patients by ensuring that they maintain a healthy body weight, are engaging in weight-bearing exercise, and have adequate nutritional intake of calcium and vitamin D. Routine imaging with DXA scans isn't recommended at this time, she notes.

— Source: Endocrine Society