Possible Link Between Processed Foods
and Autoimmune Diseases

In today's hustle-and-bustle world, processed foods are commonplace time savers. But that convenience factor may come with a bigger price tag than previously known, says an international team of researchers. In findings published in Autoimmunity Reviews, researchers from Israel and Germany present evidence that processed foods weaken the intestine's resistance to bacteria, toxins, and other hostile nutritional and nonnutritional elements, which in turn increases the likelihood of developing autoimmune diseases.

The study was led by Professor Aaron Lerner, MD, MHA, of the Technion Faculty of Medicine and Carmel Medical Center in Haifa, Israel, and Torsten Matthias, PhD, of the Aesku-Kipp Institute in Germany.

The research team examined the effects of processed food on the intestines, and on the development of autoimmune diseases—conditions in which the body attacks and damages its own tissues. More than 100 such diseases have been identified, including type 1 diabetes, celiac disease, lupus, multiple sclerosis, autoimmune hepatitis, and Crohn's disease.

"In recent decades there's been a decrease in incidence of infectious diseases, but at the same time there's been an increase in the incidence of allergic diseases, cancer, and autoimmune diseases," Lerner says. "Since the weight of genetic changes is insignificant in such a short period, the scientific community is searching for the causes at the environmental level."

In their study, the researchers focus on the dizzying increase in the use of industrial food additives aimed at improving qualities such as taste, smell, texture, and shelf life, and found "a significant circumstantial connection between the increased use of processed foods and the increase in the incidence of autoimmune diseases."

Many autoimmune diseases stem from damage to the functioning of the tight junctions that protect the intestinal mucosa. When functioning normally, tight junctions serve as barriers against bacteria, toxins, allergens, and carcinogens, protecting the immune system from them. Damage to the tight junctions (also known as "leaky gut") leads to the development of autoimmune diseases.

The researchers found that at least seven common food additives weaken the tight junctions: glucose (sugars), sodium (salt), fat solvents (emulsifiers), organic acids, gluten, microbial transglutaminase (a special enzyme that serves as food protein "glue"), and nanometric particles.

"Control and enforcement agencies such as the FDA stringently supervise the pharmaceutical industry, but the food additive market remains unsupervised," Lerner says. "We hope this study and similar studies increase awareness about the dangers inherent in industrial food additives, and raise awareness about the need for control over them."

The researchers also advise patients with autoimmune diseases, and those who have a family background of such diseases, to consider avoiding processed foods when possible.

— Source: American Technion Society