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'Western' Maternal Diet May Increase Children's Obesity Risk

Diet composition around the time of pregnancy may influence whether offspring become obese, according to a new study using animal models at The Scripps Research Institute (TSRI).

"Your diet itself matters, not just whether you are gaining excess weight or developing gestational diabetes," says TSRI Associate Professor Eric Zorrilla, PhD, who led the study in collaboration with Tim R. Nagy, PhD, of the University of Alabama at Birmingham, and Barry E. Levin, MD, of the VA Medical Center of East Orange, New Jersey, and Rutgers University.

In fact, the researchers found that giving females a typical American, or Western, diet appeared to set up the next generation for lifelong obesity issues.

This work was published recently in the American Journal of Physiology and featured in APSselect, a collection of distinguished research papers from all journals published by the American Physiological Society.

Not Just About Weight
The researchers made this discovery by studying two lines of rats: one selectively bred to be obesity-resistant to a high-fat diet and one bred to be unusually vulnerable. Rats from each group were fed either a diet with the same overall fat, saturated fat, carbohydrate, and protein levels as a typical Western diet, or a lower fat, higher grain control diet.

The scientists found that female rats given a Western diet in the weeks leading up to pregnancy, during pregnancy, and during nursing had offspring more prone to obesity at birth, during early adolescence, and—many months later—through adulthood. This occurred even if the mothers themselves didn't overeat and maintained a healthy weight, body fat, and insulin status.

Zorrilla says the results were surprising because, whereas previous studies had shown that overweight mothers were more likely to have overweight offspring, the new findings suggest that diet alone can make a difference independent of weight gain.

The Western diet seemed to set in motion a metabolic "program" that lasted throughout the rat's life. Although these rats slimmed down during puberty and early adulthood, they still showed a lower basal metabolic rate (less energy expended while at rest) and higher food intake during that time, which led to a return of obesity in midadulthood.

"What we found interesting was that you sometimes see the same thing in humans, when a kid goes through a growth spurt," says study first author Jen Frihauf, PhD, who recently completed her PhD through the University of California, San Diego, while working in the Zorrilla lab at TSRI.

The researchers also spotted an interesting difference in the effects of the Western diet between the obesity-vulnerable and obesity-resistant lines: In females, the diet impaired the reproduction of the obesity-vulnerable lines. Significantly fewer females were able to reproduce, and those that did reproduce had fewer offspring. "This wasn't the focus of the study, but it supports the idea that a Western diet promotes infertility in mothers vulnerable to diet-induced obesity," Zorrilla says.

The researchers also identified elevated levels of several molecules, such as insulin and the hormones leptin and adiponectin, starting at birth in both the Western diet and genetically vulnerable offspring. This hormone profile may serve as an early biomarker for detecting obesity risk.

Takeaway for Moms: Better Nutrition
Research is ongoing into which aspects of a Western diet trigger these effects—and the molecular changes in the offspring responsible for them. Zorrilla says the findings should raise awareness of the importance of a healthful pre- and postnatal diet. For example, doctors may want to discuss nutrition with all women who are pregnant or are planning to become pregnant, not just those already overweight.

"Doctors often use weight gain as a hallmark of a healthy pregnancy," Frihauf says. "But we realized there was something going on in utero that wasn't detectable in the mother's weight."

Frihauf adds that few pregnant women, even in the United States, eat a high-fat, high-sugar diet all day, every day. "We're not trying to tell pregnant women not to occasionally splurge on a piece of cake," she says.

Studies also have shown that paternal diet, through "epigenetic" mechanisms that control how genes are expressed, can affect obesity risk in offspring, Zorrilla adds, so nutritional information may be valuable for potential fathers as well.

— Source: Scripps Research Institute

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